Article
Low mutation percentage of KRAS and BRAF genes in Brazilian anal tumors.
Molecular medicine reports - 1 Oct 2016
Bidinotto Lucas Tadeu, Véo Carlos A R, Loaiza Edgar Aleman, De França Alessandra Paulino Santos, Lorenzi Adriana Tarla, Rosa Luciana Albina Reis, De Oliveira Cristina Mendes, Levi José Eduardo, Scapulatempo-Neto Cristovam, Longatto-Filho Adhemar, Reis Rui Manuel
Abstract excerpt
Anal cancer is a rare type of digestive tract disease, which has had a crescent incidence in a number of regions. Carcinomas are most frequently found, with squamous cell carcinoma (SCC) comprising ~95% of all anal tumors. The major risk factor for development of this type of tumor is human papillomavirus (HPV) infection. However, previous studies have identified patients with anal cancer that are HPV‑/p16‑and...
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