Article
Elevated Clonal Hematopoiesis in 9/11 First Responders Has Distinct Age-related Patterns and Relies on IL1RAP for Clonal Expansion.
Cancer discovery - 2 Dec 2025
Verma Divij, Zeig-Owens Rachel, Goldfarb David G, Kravets Leah, Pradhan Kith, Rockwell Bradley, Sahu Srabani, Kelly Susheian, Giricz Orsi, Jasra Sakshi, Zou Yiyu, Prophete Colette, Torres Lidiane S, Aluri Srinivas, Chakraborty Samarpana, Kumari Rajni, Gordon-Mitchell Shanisha, Wang Jingli, Silver Alexander J, South Taylor M, Olmstead Sarah D, Hall Charles B, Sidoli Simone, Bender Ryan, Landgren Ola, Greenberger Lee M, Wickrema Amittha, Madireddy Advaitha, Shastri Aditi, Pietras Eric M, LaFave Lindsay M, Nolan Anna, Cohen Mitchell D, Savona Michael R, Steidl Ulrich, Prezant David J, Verma Amit
Abstract excerpt
Environmental exposures are linked to precancerous hematologic conditions, but studies in cohorts with well-defined exposures are limited. We sequenced blood samples from a large cohort of first responders exposed to the aerosolized dust and carcinogens from the 9/11 World Trade Center (WTC) disaster and observed a significantly higher prevalence of clonal hematopoiesis (CH) mutations when compared with two sets...
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