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Article

Increased clonal hematopoiesis involving DNA damage response genes in patients undergoing lung transplantation.

JCI insight - 10 Apr 2023

Tague Laneshia K, Oetjen Karolyn A, Mahadev Anirudh, Walter Matthew J, Anthony Hephzibah, Kreisel Daniel, Link Daniel C, Gelman Andrew E

Abstract excerpt

BACKGROUNDCellular stressors influence the development of clonal hematopoiesis (CH). We hypothesized that environmental, inflammatory, and genotoxic stresses drive the emergence of CH in lung transplant recipients. METHODSWe performed a cross-sectional cohort study of 85 lung transplant recipients to characterize CH prevalence. We evaluated somatic variants using duplex error-corrected sequencing and germline...

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Identifiers

PMID: 36853803
DOI: 10.1172/jci.insight.165609
PMCID: PMC10132147

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