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Article

Physiologically Based Pharmacokinetic Model of the CYP2D6 Probe Atomoxetine: Extrapolation to Special Populations and Drug-Drug Interactions.

Drug metabolism and disposition: the biological fate of chemicals - 1 Nov 2017

Huang Weize, Nakano Mariko, Sager Jennifer, Ragueneau-Majlessi Isabelle, Isoherranen Nina

Abstract excerpt

Physiologically based pharmacokinetic (PBPK) modeling of drug disposition and drug-drug interactions (DDIs) has become a key component of drug development. PBPK modeling has also been considered as an approach to predict drug disposition in special populations. However, whether models developed and validated in healthy populations can be extrapolated to special populations is not well established. The goal of...

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Identifiers

PMID: 28860113
DOI: 10.1124/dmd.117.076455
PMCID: PMC5637815

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