Potential causal effect of SLE on osteoporosis, and the mediation effect: a Mendelian randomisation study.

doi:10.1136/lupus-2025-001735

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Article

Potential causal effect of SLE on osteoporosis, and the mediation effect: a Mendelian randomisation study.

Lupus science & medicine - 29 Sept 2025

Wang Zhaoqing, Yang Jiaxuan, Shi Qingya, Liu Bojie, Liang Ying, Zhou Yangzhong, Li Guanqiao

Abstract excerpt

OBJECTIVE: This study uses Mendelian randomisation (MR) to investigate the causal link between SLE and osteoporosis across different ethnic groups. METHODS: Genetic variants associated with SLE were identified from publicly available genome-wide association studies in European and East Asian populations. Two-sample MR (TSMR) analysis and meta-analysis with inverse variance weighting (IVW) assessed their effects...

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Topics

Female
Humans
Asian People
Bone Density
Fractures, Bone
Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Genome-Wide Association Study

Lupus Erythematosus, Systemic

Mediation Analysis

Mendelian Randomization Analysis

Osteoporosis

Polymorphism, Single Nucleotide

Risk Factors

White People

Source

Open in PubMed Open full text

Identifiers

PMID: 41027686
DOI: 10.1136/lupus-2025-001735
PMCID: PMC12481273

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