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Article

HIV-1 adaptation studies reveal a novel Env-mediated homeostasis mechanism for evading lethal hypermutation by APOBEC3G.

PLoS pathogens - 1 Apr 2018

Ikeda Terumasa, Symeonides Menelaos, Albin John S, Li Ming, Thali Markus, Harris Reuben S

Abstract excerpt

HIV-1 replication normally requires Vif-mediated neutralization of APOBEC3 antiviral enzymes. Viruses lacking Vif succumb to deamination-dependent and -independent restriction processes. Here, HIV-1 adaptation studies were leveraged to ask whether viruses with an irreparable vif deletion could develop resistance to restrictive levels of APOBEC3G. Several resistant viruses were recovered with multiple amino acid...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to vif Gene Products, Human Immunodeficiency Virus

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Identifiers

PMID: 29677220
DOI: 10.1371/journal.ppat.1007010
PMCID: PMC5931688

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