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Article

Conditional gene targeting of the ENaC subunit genes Scnn1b and Scnn1g.

American journal of physiology. Renal physiology - 1 Feb 2009

Mérillat Anne-Marie, Charles Roch-Philippe, Porret Andrée, Maillard Marc, Rossier Bernard, Beermann Friedrich, Hummler Edith

Abstract excerpt

Epithelial sodium channels (ENaC) are members of the degenerin/ENaC superfamily of non-voltage-gated, highly amiloride-sensitive cation channels that are composed of three subunits (alpha-, beta-, and gamma-ENaC). Since complete gene inactivation of the beta- and gamma-ENaC subunit genes (Scnn1b and Scnn1g) leads to early postnatal death, we generated conditional alleles and obtained mice harboring floxed and...

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PMID: 19036848
DOI: 10.1152/ajprenal.00612.2007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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