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Article

Inferring germline pharmacogenomics from tumor transcriptome.

Pharmacogenetics and genomics - 1 Jan 2026

Yang Wenjian, Wu Gang, Klco Jeffery M, Nichols Kim E, Jeha Sima, Inaba Hiroto, Pui Ching-Hon, Bhakta Nickhill, Broeckel Ulrich, Yang Jun J, Haidar Cyrine E

Abstract excerpt

OBJECTIVES: Pharmacogenomic testing is rapidly becoming the standard of care in treating pediatric acute lymphoblastic leukemia (ALL). Risk classification of ALL can be performed through whole transcriptome sequencing (WTS) of diagnostic tumor samples. We evaluated the feasibility of inferring germline pharmacogenomic genotypes from the tumor transcriptome in ALL. METHODS: Transcriptome and paired tumor-germline...

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Share to Germ Cells
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 40995674
DOI: 10.1097/FPC.0000000000000576

Genes

G6PD
NUDT15
TPMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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