Article
Distribution of fixed beneficial mutations and the rate of adaptation in asexual populations.
Proceedings of the National Academy of Sciences of the United States of America - 27 Mar 2012
Good Benjamin H, Rouzine Igor M, Balick Daniel J, Hallatschek Oskar, Desai Michael M
Abstract excerpt
When large asexual populations adapt, competition between simultaneously segregating mutations slows the rate of adaptation and restricts the set of mutations that eventually fix. This phenomenon of interference arises from competition between mutations of different strengths as well as competition between mutations that arise on different fitness backgrounds. Previous work has explored each of these effects in...
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