Article
The distribution of fitness effects during adaptive walks using a simple genetic network.
PLoS genetics - 1 May 2024
O'Brien Nicholas L V, Holland Barbara, Engelstädter Jan, Ortiz-Barrientos Daniel
Abstract excerpt
The tempo and mode of adaptation depends on the availability of beneficial alleles. Genetic interactions arising from gene networks can restrict this availability. However, the extent to which networks affect adaptation remains largely unknown. Current models of evolution consider additive genotype-phenotype relationships while often ignoring the contribution of gene interactions to phenotypic variance. In this...
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