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Phenotypes of antigen-induced responses in guinea pigs: Beyond the asthma model.

Molecular immunology - 1 Mar 2025

Álvarez-González Marisol, Pacheco-Alba Ivonne, Moreno-Álvarez Paola, Rogel-Velasco Lizbeth, Guerrero-Clorio Silvia, Flores-Flores Angélica, Téllez-Araiza Mariana, Arellano-García Juana, Quevedo-Razo Angel, Flores-Martínez Angélica, Bazán-Perkins Blanca

Abstract excerpt

Asthma is a heterogeneous and variable disease. In an allergic asthma model using guinea pigs (GPs), we identified three distinct phenotypes: those always showing an obstructive response (R), those never responding (NR), and those sometimes responding (VR). We aimed to assess and compare the functional and immunological characteristics of these groups. GPs were sensitized and challenged with ovalbumin (OVA) every...

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PMID: 39892125
DOI: 10.1016/j.molimm.2025.01.014

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