Article
Mapping phenotypic and genetic relationships among irritability, depression and ADHD in adolescence using network analysis.
Journal of child psychology and psychiatry, and allied disciplines - 1 Mar 2026
Shakeshaft Amy, Farhat Luis C, Dennison Charlotte A, Eyre Olga, Oginni Olakunle, O'Donovan Michael C, Stringaris Argyris, Leibenluft Ellen, Polanczyk Guilherme V, Riglin Lucy, Thapar Anita
Abstract excerpt
BACKGROUND: Irritability is a common reason for referral to child and adolescent mental health services. However, debate exists as to whether irritability is best conceptualised and treated as a feature of mood disorder, oppositional defiant disorder or a core symptom of ADHD. METHODS: We use network analyses to examine the relationships between adolescent irritability, headstrong/hurtful ODD items, depression...
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