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Article

Adolescent irritability: phenotypic associations and genetic links with depressed mood.

The American journal of psychiatry - 1 Jan 2012

Stringaris Argyris, Zavos Helena, Leibenluft Ellen, Maughan Barbara, Eley Thalia C

Abstract excerpt

OBJECTIVE: Irritability has been proposed to underlie the developmental link between oppositional problems and depression. Little is known, however, about the genetic and environmental influences on irritability and its overlap with depression. Drawing on the notion of "generalist genes" (genes of general effect that underlie phenotypic overlap between disorders), the authors test the hypothesis that the...

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Identifiers

PMID: 22193524
DOI: 10.1176/appi.ajp.2011.10101549
PMCID: PMC3660701

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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