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A genome-wide investigation of depression among individuals with and without irritability.

Molecular psychiatry - 1 Aug 2026

St-Pierre Julien, Jang Jacky, Nagy Corina, Fiori Laura, Turecki Gustavo, Dupuis Josée, Bhatnagar Sahir Rai, Orri Massimiliano

Abstract excerpt

Individuals presenting with both depression and irritability may constitute a different group of individuals with respect to those presenting without irritability, but their biological differences remain unknown. We aimed to identify genetic variants associated with depression among individuals with and without irritability, highlight biological pathways, and test for genetic associations with other traits. We...

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PMID: 41872521
DOI: 10.1038/s41380-026-03548-w

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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