Article

Decomposing genetic effects of social connectedness and depression on youth behaviors and long-term clinical outcomes

2025-11-23

Abstract excerpt

<h4>Importance</h4> Lacking social connectedness is associated with broad morbidity. Yet the underlying mechanisms remain obscures, especially given its entanglement with depressive symptoms. Clarifying whether social connectedness confers unique risk beyond depression can guide clinical care and social infrastructure interventions. <h4>Objective</h4> To decompose shared genetic architecture between social conne...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 40c20982-e985-5225-a4e4-729db541cea5
DOI: 10.1101/2025.11.21.25340781

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Decomposing genetic effects of social connectedness and depression on youth behaviors and long-term clinical outcomesDOI 10.1101/2025.11.21.25340781Read

Understanding the relationship between loneliness, substance use traits and psychiatric disorders: A genetically informed approach.Semantic proximity Read

Effects of depression genetic risk and household socioeconomic status on emotional behavior and brain development in early adolescenceSemantic proximity Read

A multidimensional social risk atlas of depression and anxiety: An observational and genome-wide environmental interaction study.Semantic proximity Read

Intra-familial dynamics of mental distress during the Covid-19 lockdown.Semantic proximity Read

Polygenic risk of social isolation behavior and its influence on psychopathology and personality.Semantic proximity Read

Mapping phenotypic and genetic relationships among irritability, depression and ADHD in adolescence using network analysis.Semantic proximity Read

Social connectedness as a determinant of mental health: A scoping reviewSemantic proximity Read

Polygenic Scores and Networks of Psychopathology Symptoms.Semantic proximity Read

Examining Differences in the Genetic and Functional Architecture of ADHD Diagnosed in Childhood and AdulthoodSemantic proximity Read

Saguenay Youth Study: a multi-generational approach to studying virtual trajectories of the brain and cardio-metabolic health.Semantic proximity Read

Effects of genetic risk for depression and household socioeconomic status on emotional behavior and brain development in early adolescence.Semantic proximity Read

Unique prediction of developmental psychopathology from genetic and familial riskSemantic proximity Read