Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Article

Investigating the genetic underpinnings of early-life irritability.

Translational psychiatry - 26 Sept 2017

Riglin L, Eyre O, Cooper M, Collishaw S, Martin J, Langley K, Leibenluft E, Stringaris A, Thapar A K, Maughan B, O'Donovan M C, Thapar A

Abstract excerpt

Severe irritability is one of the commonest reasons prompting referral to mental health services. It is frequently seen in neurodevelopmental disorders that manifest early in development, especially attention-deficit/hyperactivity disorder (ADHD). However, irritability can also be conceptualized as a mood problem because of its links with anxiety/depressive disorders; notably DSM-5 currently classifies severe,...

Topics

Join the communities discussing this publication.

Adolescent
Attention Deficit Disorder with Hyperactivity
Child
Depressive Disorder, Major
Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genome-Wide Association Study

Longitudinal Studies

Multifactorial Inheritance

Source

Open in PubMed Open full text

Identifiers

PMID: 28949337
DOI: 10.1038/tp.2017.212
PMCID: PMC5639253

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Investigating the genetic underpinnings of early-life irritability.PMID 28949337Read ↗

Mapping phenotypic and genetic relationships among irritability, depression and ADHD in adolescence using network analysis.Semantic proximity Read ↗

Systematic review of genetic associations between irritability and mental health disordersSemantic proximity Read ↗

Leveraging genetic overlap between irritability and psychiatric disorders to identify genetic variants of major psychiatric disorders.Semantic proximity Read ↗

Annual research review: Rare genotypes and childhood psychopathology--uncovering diverse developmental mechanisms of ADHD risk.Semantic proximity Read ↗

The genetic architecture of differentiating behavioural and emotional problems in early lifeSemantic proximity Read ↗

The Evolving ADHD Phenotype in the Externalizing Context.Semantic proximity Read ↗

Estimating the impact of transmitted and non-transmitted psychiatric and neurodevelopmental polygenic scores on youth emotional problems.Semantic proximity Read ↗

The impact of schizophrenia and mood disorder risk alleles on emotional problems: investigating change from childhood to middle age.Semantic proximity Read ↗

Examining Differences in the Genetic and Functional Architecture of ADHD Diagnosed in Childhood and AdulthoodSemantic proximity Read ↗

The contribution of common genetic risk variants for ADHD to a general factor of childhood psychopathologySemantic proximity Read ↗

Irritability in young people with copy number variants associated with neurodevelopmental disorders (ND-CNVs)Semantic proximity Read ↗

A genome-wide investigation of depression among individuals with and without irritability.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.