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Article

An insulator loop resides between the synthetically interacting elements of the human/rat conserved breast cancer susceptibility locus MCS5A/Mcs5a.

Nucleic acids research - 1 Jan 2012

Smits Bart M G, Traun Benjamin D, Devries Thomas L, Tran Ann, Samuelson David, Haag Jill D, Gould Michael

Abstract excerpt

Many low-penetrance breast cancer susceptibility loci are found to be located in non-protein-coding regions, suggesting their involvement in gene expression regulation. We identified the human/rat-conserved breast cancer susceptibility locus MCS5A/Mcs5a. This locus has been shown to act in a non-mammary cell-autonomous fashion through the immune system. The resistant Mcs5a allele from the Wistar-Kyoto (WKy) rat...

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Identifiers

PMID: 21914726
DOI: 10.1093/nar/gkr610
PMCID: PMC3245909

Genes

CTCF
TOMM5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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