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Article

Role of nucleophosmin 1 immunostain in detecting leukemia cutis of acute myeloid leukemia with NPM1 mutation.

American journal of clinical pathology - 19 Nov 2025

Segura Rossana N Lazcano, Nardi Valentina, Hoang Mai P

Abstract excerpt

OBJECTIVE: The role of NPM1 immunostaining as a surrogate marker for acute myeloid leukemia (AML) with nucleophosmin (NPM1) mutation (AML-NPM1) in leukemia cutis has not been investigated. METHODS: NPM1 immunostaining was performed using a polyclonal antibody on leukemia cutis diagnosed in 2017-2024 of 15 patients with and 15 without the NPM1 mutation. Targeted next-generation sequencing assays were performed on...

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Identifiers

PMID: 40972674
DOI: 10.1093/ajcp/aqaf089

Genes

NPM1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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