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Intratumor heterogeneity, microenvironment, and mechanisms of drug resistance in glioma recurrence and evolution.

Frontiers of medicine - 1 Aug 2021

Bao Zhaoshi, Wang Yongzhi, Wang Qiangwei, Fang Shengyu, Shan Xia, Wang Jiguang, Jiang Tao

Abstract excerpt

Glioma is the most common lethal tumor of the human brain. The median survival of patients with primary World Health Organization grade IV glioma is only 14.6 months. The World Health Organization classification of tumors of the central nervous system categorized gliomas into lower-grade gliomas and glioblastomas. Unlike primary glioblastoma that usually develop de novo in the elderly, secondary glioblastoma...

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Brain Neoplasms
Drug Resistance
Glioblastoma
Glioma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neoplasm Recurrence, Local

Tumor Microenvironment

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PMID: 33893983
DOI: 10.1007/s11684-020-0760-2

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