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Article

Spatially aware deep learning reveals tumor heterogeneity patterns that encode distinct kidney cancer states.

Cell reports. Medicine - 19 Sept 2023

Nyman Jackson, Denize Thomas, Bakouny Ziad, Labaki Chris, Titchen Breanna M, Bi Kevin, Hari Surya Narayanan, Rosenthal Jacob, Mehta Nicita, Jiang Bowen, Sharma Bijaya, Felt Kristen, Umeton Renato, Braun David A, Rodig Scott, Choueiri Toni K, Signoretti Sabina, Van Allen Eliezer M

Abstract excerpt

Clear cell renal cell carcinoma (ccRCC) is molecularly heterogeneous, immune infiltrated, and selectively sensitive to immune checkpoint inhibition (ICI). However, the joint tumor-immune states that mediate ICI response remain elusive. We develop spatially aware deep-learning models of tumor and immune features to learn representations of ccRCC tumors using diagnostic whole-slide images (WSIs) in untreated and...

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Identifiers

PMID: 37729872
DOI: 10.1016/j.xcrm.2023.101189
PMCID: PMC10518628

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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