Genomic and Transcriptomic Analysis of High-Grade Endometrial Carcinoma Reveals Biological Heterogeneity and Molecular Classification Challenges.

doi:10.1158/2767-9764.CRC-25-0589

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Genomic and Transcriptomic Analysis of High-Grade Endometrial Carcinoma Reveals Biological Heterogeneity and Molecular Classification Challenges.

Cancer research communications - 1 Apr 2026

Kawazu Masahito, Taguchi Ayumi, Yoshida Emiko, Yoshida Hiroshi, Uno Masaya, Inoue Satoshi, Yamamoto Yoko, Sakashita Shingo, Ueno Toshihide, Nakamura Yuki, Lin Jason, Kojima Shinya, Kawase Katsushige, Ishizaka Aya, Miyata Suguru, Kojima Motohiro, Ikemura Masako, Sone Kenbun, Ishikawa Mitsuya, Kato Tomoyasu, Mano Hiroyuki, Terao Yasuhisa, Oda Katsutoshi

Abstract excerpt

High-grade endometrial carcinoma exhibits marked histologic diversity, yet its molecular basis and the potential contribution of transcriptomic phenotyping to molecular classification remain incompletely understood. To address this, we performed whole-exome sequencing and RNA sequencing on 81 high-grade endometrial carcinomas, including serous, clear cell, grade 3 endometrioid, and carcinosarcoma. Tumors were...

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PMID: 41911343
DOI: 10.1158/2767-9764.CRC-25-0589
PMCID: PMC13123251

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TP53
POLE

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