Article
TCGA Molecular Prognostic Groups of Endometrial Carcinoma: Current Knowledge and Future Perspectives.
International journal of molecular sciences - 2 Oct 2022
Arciuolo Damiano, Travaglino Antonio, Raffone Antonio, Raimondo Diego, Santoro Angela, Russo Daniela, Varricchio Silvia, Casadio Paolo, Inzani Frediano, Seracchioli Renato, Mollo Antonio, Mascolo Massimo, Zannoni Gian Franco
Abstract excerpt
The four TCGA-based molecular prognostic groups of endometrial carcinoma (EC), i.e., POLE-mutant, mismatch repair (MMR)-deficient, p53-abnormal, and “no specific molecular profile” (NSMP), have recently been integrated into ESGO-ESTRO-ESP guidelines. The POLE-mutant and MMR-deficient groups are associated with high mutational load, morphological heterogeneity, and inflammatory infiltration. These groups are...
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