Article
Polymorphisms at LDLR locus may be associated with coronary artery disease through modulation of coagulation factor VIII activity and independently from lipid profile.
Blood - 16 Dec 2010
Martinelli Nicola, Girelli Domenico, Lunghi Barbara, Pinotti Mirko, Marchetti Giovanna, Malerba Giovanni, Pignatti Pier Franco, Corrocher Roberto, Olivieri Oliviero, Bernardi Francesco
Abstract excerpt
High levels of coagulation factor VIII (FVIII) have been associated with cardiovascular disease. Low-density lipoprotein receptor (LDLR) has been recently demonstrated to contribute to FVIII clearance from plasma. The aim of this study was to evaluate 3 single nucleotide polymorphisms in SMARCA4-LDLR gene locus (rs1122608, rs2228671, and rs688) and FVIII coagulant activity (FVIII:c) in subjects with (n = 692) or...
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