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Article

A mutagenesis-derived Lrp5 mouse mutant with abnormal retinal vasculature and low bone mineral density.

Molecular vision - 1 Jan 2017

Charette Jeremy R, Earp Sarah E, Bell Brent A, Ackert-Bicknell Cheryl L, Godfrey Dana A, Rao Sujata, Anand-Apte Bela, Nishina Patsy M, Peachey Neal S

Abstract excerpt

PURPOSE: Familial exudative vitreoretinopathy (FEVR) is caused by mutations in the genes encoding low-density lipoprotein receptor-related protein (LRP5) or its interacting partners, namely frizzled class receptor 4 (FZD4) and norrin cystine knot growth factor (NDP). Mouse models for Lrp5, Fzd4, and Ndp have proven to be important for understanding the retinal pathophysiology underlying FEVR and systemic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28356706
PMCID: PMC5360454

Genes

LRP5
ERG
FZD4
NDP

Variants

Provenance

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