Article
Multi-ancestry eQTL meta-analysis of human brain identifies candidate causal variants for brain-related traits.
Nature genetics - 1 Feb 2022
Zeng Biao, Bendl Jaroslav, Kosoy Roman, Fullard John F, Hoffman Gabriel E, Roussos Panos
Abstract excerpt
While large-scale, genome-wide association studies (GWAS) have identified hundreds of loci associated with brain-related traits, identification of the variants, genes and molecular mechanisms underlying these traits remains challenging. Integration of GWAS with expression quantitative trait loci (eQTLs) and identification of shared genetic architecture have been widely adopted to nominate genes and candidate...
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