Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genome-wide phenotypic insights into mycobacterial virulence using Drosophila melanogaster.

PLoS pathogens - 1 Sept 2025

Sivakumar Niruja, Fuentes Esther, Selvik Linn-Karina, Arch Marta, Ås Christina Gabrielsen, Cardona Pere-Joan, Ioerger Thomas R, Dragset Marte Singsås

Abstract excerpt

Drosophila melanogaster (Drosophila) is one of the most extensively studied animal models we have, with a broad, advanced, and organized research community. Yet, Drosophila has barely been exploited to understand the underlying mechanisms of mycobacterial infections, which cause some of the deadliest infectious diseases humans are currently battling. Here, we identified mycobacterial genes required for the...

Read the complete abstract on PubMed

Topics

Animals
Drosophila melanogaster
Mycobacterium marinum
Virulence
Virulence Factors
Disease Models, Animal

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Humans

Phenotype

Bacterial Proteins

Mycobacterium tuberculosis

Mycobacterium Infections, Nontuberculous

Genome, Bacterial

Source

Open in PubMed Open full text

Identifiers

PMID: 40911634
DOI: 10.1371/journal.ppat.1013474
PMCID: PMC12425279

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genome-wide phenotypic insights into mycobacterial virulence using Drosophila melanogaster.PMID 40911634Read ↗

<i>Drosophila melanogaster</i> is a powerful host model to study mycobacterial virulenceSemantic proximity Read ↗

High-throughput functional genomics: A (myco)bacterial perspective.Semantic proximity Read ↗

High-throughput characterization of Mycobacterium tuberculosis gene function across diverse conditions.Semantic proximity Read ↗

Comprehensive analysis of iron utilization by Mycobacterium tuberculosis.Semantic proximity Read ↗

Drosophila as a Model for Infectious DiseasesSemantic proximity Read ↗

The secret lives of mycobacteriophages.Semantic proximity Read ↗

Genome-wide screen identifies host loci that modulate Mycobacterium tuberculosis fitness in immunodivergent miceSemantic proximity Read ↗

Transposon sequencing reveals metabolic pathways essential for Mycobacterium tuberculosis infection.Semantic proximity Read ↗

<i>Mycobacterium tuberculosis</i> requires conditionally essential metabolic pathways for infectionSemantic proximity Read ↗

Lipid metabolism and Type VII secretion systems dominate the genome scale virulence profile of Mycobacterium tuberculosis in human dendritic cells.Semantic proximity Read ↗

Towards next generation diagnostics for tuberculosis: identification of novel molecular targets by large-scale comparative genomicsSemantic proximity Read ↗

Identification of Novel Virulence Determinants inMycobacterium paratuberculosisby Screening a Library of Insertional MutantsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.