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Article

Phylodynamic estimation of the within-host evolutionary rate of extended-spectrum beta-lactamase-producing Enterobacterales.

Microbial genomics - 1 Sept 2025

Windels Etthel M, Aguilar-Bultet Lisandra, Vock Isabelle, Maurer Pekerman Laura, Tschudin-Sutter Sarah, Stadler Tanja

Abstract excerpt

Despite their clinical relevance, the within-host evolution of extended-spectrum beta-lactamase (ESBL)-producing Enterobacterales is still poorly understood. To estimate the within-host evolutionary rates of ESBL-producing Escherichia coli and Klebsiella pneumoniae species complex, we fitted phylodynamic models to genomic sequence data of longitudinally collected rectal swabs from 63 colonized hospital patients....

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Identifiers

PMID: 40911034
DOI: 10.1099/mgen.0.001499
PMCID: PMC12413297

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