Article
Within-host evolution of Enterococcus faecium during longitudinal carriage and transition to bloodstream infection in immunocompromised patients.
Genome medicine - 27 Dec 2017
Moradigaravand Danesh, Gouliouris Theodore, Blane Beth, Naydenova Plamena, Ludden Catherine, Crawley Charles, Brown Nicholas M, Török M Estée, Parkhill Julian, Peacock Sharon J
Abstract excerpt
BACKGROUND: Enterococcus faecium is a leading cause of hospital-acquired infection, particularly in the immunocompromised. Here, we use whole genome sequencing of E. faecium to study within-host evolution and the transition from gut carriage to invasive disease. METHODS: We isolated and sequenced 180 E. faecium from four immunocompromised patients who developed bloodstream infection during longitudinal...
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