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Article

Myeloid sarcoma shows a high frequency of mutations activating the MAPK/ERK pathway and association with clonal hematopoiesis.

The journal of pathology. Clinical research - 1 Sept 2025

Nann Dominik, Schade Tim-Colin, Overkamp Mathis, Mahmutovic Lejla, Bag Eyyub, Forchhammer Stephan, Slotta-Huspenina Julia, Boudova Ludmila, Sotlar Karl, Quintanilla-Martinez Leticia, Bonzheim Irina, Fend Falko

Abstract excerpt

Myeloid sarcoma (MS) is a mass-forming extramedullary manifestation of myeloid blasts, either in relation to an underlying acute myeloid leukemia (AML), another myeloid neoplasm (MN) or as a de novo occurrence. Data on the genetic profile of MS are sparse. In this study, 41 MS of 34 patients, including 7 de novo cases and 24 patients with antecedent or synchronous MN, were analyzed with targeted next-generation...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40906433
DOI: 10.1002/2056-4538.70044
PMCID: PMC12410091

Genes

NRAS
TET2
NPM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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