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A combined enteric neuron-gastric tumor organoid reveals metabolic vulnerabilities in gastric cancer

2 Sept 2025

Abstract excerpt

) values across diverse human gastric cancer organoids resistant to first-line treatments. Mechanistically, gastric cancer organoids and in vivo tumors exhibit lipid metabolic adaptations not seen in two-dimensional (2D) in vitro cultures. Additionally, enteric neurons modulate lipid metabolism in tumor organoids, altering drug sensitivity by up to two orders of magnitude. A neuron-cocultured CRISPR screen...

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PMID: 40902593
DOI: 10.1016/j.stem.2025.08.006

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