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An approach using Caenorhabditis elegans screening novel targets to suppress tumour cell proliferation.

Cell proliferation - 1 Jun 2020

Mao Yu-Qin, Han San-Feng, Zhang Shi-Long, Zhang Zheng-Yan, Kong Chao-Yue, Chen Hui-Ling, Li Zhan-Ming, Cai Pei-Ran, Han Bing, Wang Li-Shun

Abstract excerpt

OBJECTIVES: Tumour cell proliferation requires high metabolism to meet the bioenergetics and biosynthetic needs. Dauer in Caenorhabditis elegans is characterized by lower metabolism, and we established an approach with C elegans to find potential tumour therapy targets. MATERIALS AND METHODS: RNAi screening was used to find dauer-related genes, and these genes were further analysed in glp-1(-) mutants for...

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Identifiers

PMID: 32452127
DOI: 10.1111/cpr.12832
PMCID: PMC7309951

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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