A national cohort study of melanoma BRAF status, testing patterns, patient and tumour characteristics, treatment and survival in England from 2016 to 2021.

doi:10.1093/bjd/ljaf351

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Article

A national cohort study of melanoma BRAF status, testing patterns, patient and tumour characteristics, treatment and survival in England from 2016 to 2021.

The British journal of dermatology - 18 Nov 2025

Mistry Khaylen, Jeffrey Polly, Levell Nick J, Kennedy Oliver, Richardson Kathryn, Craig Paul, Bright Chloe, Taylor Siobhan, Ragan John, Karponis Dimitrios, Pethick Joanna, Lavelle Katrina, McRonald Fiona, Hardy Steven, Vernon Sally, Lorigan Paul, Venables Zoe C

Abstract excerpt

BACKGROUND: Inadequacy of testing for melanoma BRAF status results in delayed access to systemic therapy. BRAF mutations and their association with patient/tumour characteristics and survival is poorly understood. OBJECTIVES: To report national data from England on the frequency of molecular BRAF testing; the association of patient/tumour characteristics with BRAF mutations; and the treatment and survival of...

Topics

Humans
Melanoma
Proto-Oncogene Proteins B-raf
Female
Male
England
Skin Neoplasms
Middle Aged
Aged
Retrospective Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Adult

Aged, 80 and over

Young Adult

Adolescent

Genetic Testing

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Open in PubMed Open full text

Identifiers

PMID: 40902091
DOI: 10.1093/bjd/ljaf351
PMCID: PMC12626136

Genes

BRAF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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