Testing patterns, patient and tumour characteristics and survival by NRAS and KIT genotype in melanoma.

doi:10.1093/ced/llaf543

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Testing patterns, patient and tumour characteristics and survival by NRAS and KIT genotype in melanoma.

Clinical and experimental dermatology - 26 Mar 2026

Mistry Khaylen, Jeffrey Polly, Levell Nick J, Kennedy Oliver, Richardson Kathryn, Craig Paul, Bright Chloe, Taylor Siobhan, Ragan John, Karponis Dimitrios, Pethick Joanna, Lavelle Katrina, McRonald Fiona, Hardy Steven, Vernon Sally, Dawe Robert, Proby Charlotte, Lorigan Paul, Venables Zoe C

Abstract excerpt

BACKGROUND: NRAS and KIT mutations in melanoma bring implications for prognosis, follow-up, selection into trials and potential future treatment with targeted therapies. The frequency of NRAS/KIT mutations and their association with patient/tumour characteristics and survival is poorly documented. OBJECTIVES: To report national data from England on (i) the frequency of NRAS and KIT mutations, (ii) the association...

Topics

Humans
Melanoma
Proto-Oncogene Proteins c-kit
Female
Male
Membrane Proteins
GTP Phosphohydrolases
Retrospective Studies
Middle Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Skin Neoplasms

Aged

Mutation

Adult

Genotype

England

Aged, 80 and over

Young Adult

Adolescent

Source

Open in PubMed Open full text

Identifiers

PMID: 41378737
DOI: 10.1093/ced/llaf543
PMCID: PMC13020422

Genes

NRAS
KIT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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