Article
Inflammation awakens dormant cancer cells by modulating the epithelial-mesenchymal phenotypic state.
Proceedings of the National Academy of Sciences of the United States of America - 9 Sept 2025
Zhang Jingwei, Zhang Jingwen, Han Longfei, Wu Shiyi, Li Jie, Eaton Elinor Ng, Yuan Bingbing, Reinhardt Ferenc, Li Hao, Strasser Patrick C, Das Sunny, Liu Donaher Joana, Khalil Md Imtiaz, Jiang Haiping, Deuschel Alexander, Lin Danni, Sebastiany Carolin, Maranga Mariana, Shubitidze Salomé, Liu Xiaofei, Lambert Arthur W, Zhang Yun, Liu Yana, Sui Lufei, Elmiligy Sarah, Pozza Umberto, Günsay Rauf, Mishra Ranjan, Velarde Jose, Iyer Sonia, Henry Whitney S, Weiskopf Kipp, Feng Guihai, Oni Tobiloba E, Watnick Randolph S, Li Xin, Weinberg Robert A
Abstract excerpt
The awakening of dormant disseminated cancer cells appears to be responsible for the clinical relapses of patients whose primary tumors have been successfully cured months and even years earlier. In the present study, we demonstrate that dormant breast cancer cells lodged in the lungs reside in a highly mesenchymal, nonproliferative phenotypic state. The awakening of these cells is not triggered by a cancer...
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