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Article

Polygenic risk of refractory celiac disease type II and its association with autoimmune diseases: a phenome-wide association study in the UK Biobank.

European journal of gastroenterology & hepatology - 1 Dec 2025

Tsali Lampriani, Tsilidis Konstantinos, Katsanos Konstantinos, Ntzani Evangelia, Manou Maria, Papandreou Christopher, Markozannes Georgios, Chalitsios Christos V

Abstract excerpt

OBJECTIVE: Refractory celiac disease-type II (RCDII) is the more severe and adverse form of celiac disease; however, its association with other autoimmune diseases remains unclear. We conducted a phenome-wide association study (PheWAS) to examine the association between the polygenic risk score (PRS) for RCDII and autoimmune diseases. METHODS: To construct the PRS-RCDII, we extracted summary statistics for three...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40900534
DOI: 10.1097/MEG.0000000000003036
PMCID: PMC12577659

Genes

KLF12
SHISA6

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