Isolation of Synechocystis Mutants Overproducing Mannitol Directly from CO2 via Laboratory Evolution under Increasing Salt Concentration.

Abstract excerpt

Mannitol is a naturally occurring C(6) polyol with a wide range of applications in the food and pharmaceutical industry. In a previous study, mannitol production was achieved via the direct conversion of CO2 in Synechocystis sp. PCC6803. However, a major barrier to future applications of this strain was its low production rate. In this study, three mutants were isolated after 164 generations of adaptive...

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• Bacterial Proteins
• Carbon Dioxide
• Directed Molecular Evolution
• Mannitol
• Mutation