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Potential therapeutic role of sex steroids in treating sarcopenia: a network pharmacology and molecular dynamics study

1 Sept 2025

Abstract excerpt

BACKGROUND: Sarcopenia, characterized by progressive muscle loss and functional decline in aging, poses significant health challenges. Sex steroids, such as estradiol and testosterone, have potential therapeutic roles in mitigating muscle degeneration. This study explores the molecular mechanisms and targets of sex steroids in the treatment of sarcopenia using network pharmacology, enrichment analysis, machine...

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PMID: 40890834
DOI: 10.1186/s40360-025-00978-0

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