Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Potential therapeutic role of sex steroids in treating sarcopenia: a network pharmacology and molecular dynamics study

1 Sept 2025

Abstract excerpt

BACKGROUND: Sarcopenia, characterized by progressive muscle loss and functional decline in aging, poses significant health challenges. Sex steroids, such as estradiol and testosterone, have potential therapeutic roles in mitigating muscle degeneration. This study explores the molecular mechanisms and targets of sex steroids in the treatment of sarcopenia using network pharmacology, enrichment analysis, machine...

Topics

Join the communities discussing this publication.

GDF15 and Related Biomarkers
Muscle Physiology and Disorders
Nutrition and Health in Aging

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 40890834
DOI: 10.1186/s40360-025-00978-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Potential therapeutic role of sex steroids in treating sarcopenia: a network pharmacology and molecular dynamics studyPMID 40890834Read ↗

An integrated study of hormone-related sarcopenia for modeling and comparative transcriptome in ratsSemantic proximity Read ↗

Epigenetic characterization of sarcopenia-associated genes based on machine learning and network screeningSemantic proximity Read ↗

Sarcopenia and chronic pain: Identification of shared genetic determinants and therapeutic implication.Semantic proximity Read ↗

Identification of novel pathways and immune profiles related to sarcopeniaSemantic proximity Read ↗

Roles of Estrogen, Estrogen Receptors, and Estrogen-Related Receptors in Skeletal Muscle: Regulation of Mitochondrial FunctionSemantic proximity Read ↗

Dynamic transcriptomic analysis reveals suppression of PGC1α/ERRα drives perturbed myogenesis in facioscapulohumeral muscular dystrophySemantic proximity Read ↗

The mechanism of atorvastatin-induced sarcopenia elucidated based on network toxicology, single-cell RNA sequencing, and bulk transcriptomics dataSemantic proximity Read ↗

Sex differences in muscle protein expression and DNA methylation in response to exercise trainingSemantic proximity Read ↗

The influence of Sex on microRNA expression in Human Skeletal MuscleSemantic proximity Read ↗

Estrogen-related Receptor Signaling in Skeletal Muscle FitnessSemantic proximity Read ↗

Association Analysis of the Circulating Proteome With Sarcopenia‐Related Traits Reveals Potential Drug Targets for SarcopeniaSemantic proximity Read ↗

Identification of shared gene signatures and pathways for diagnosing osteoporosis with sarcopenia through integrated bioinformatics analysis and machine learningSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.