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Genome-Wide Epigenetic Signatures of Adaptive Developmental Plasticity in the Andes.

Genome biology and evolution - 3 Feb 2021

Childebayeva Ainash, Goodrich Jaclyn M, Leon-Velarde Fabiola, Rivera-Chira Maria, Kiyamu Melisa, Brutsaert Tom D, Dolinoy Dana C, Bigham Abigail W

Abstract excerpt

High-altitude adaptation is a classic example of natural selection operating on the human genome. Physiological and genetic adaptations have been documented in populations with a history of living at high altitude. However, the role of epigenetic gene regulation, including DNA methylation, in high-altitude adaptation is not well understood. We performed an epigenome-wide DNA methylation association study based on...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 33185669
DOI: 10.1093/gbe/evaa239
PMCID: PMC7859850

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