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Controlling nephron precursor differentiation to generate proximal-biased kidney organoids with emerging maturity

30 Aug 2025

Abstract excerpt

The kidney maintains fluid homeostasis by reabsorbing essential compounds and excreting waste. Proximal tubule cells, crucial for reabsorbing sugars, ions, and amino acids, are highly susceptible to injury, often leading to pathologies necessitating dialysis or transplants. Human pluripotent stem cell-derived kidney organoids offer a platform to model renal development, function, and disease, but proximal nephron...

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PMID: 40885711
DOI: 10.1038/s41467-025-63107-9

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