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Specific and redundant roles for Gli2 and Gli3 in establishing cell fate during murine hair follicle development

26 Aug 2025

Abstract excerpt

Formation of skin epithelial appendages like hair follicles requires hedgehog (Hh) signal reception, its conduction through the primary cilium and activation of Gli transcription factors. How Hh signalling induces cell-type-specific responses through Gli transcription factors in hair follicle stem cells and their cilia-dependence remains unclear. Here, we use conditional mouse mutants to genetically dissect the...

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PMID: 40859032
DOI: 10.1038/s44318-025-00519-9

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