Article
Behavioral phenotyping of transgenic and knockout mice: practical concerns and potential pitfalls.
ILAR journal - 1 Jan 2006
Bailey Kathleen R, Rustay Nathan R, Crawley Jacqueline N
Abstract excerpt
New technologies in molecular genetics have dramatically increased the number of targeted gene mutations available to the biomedical research community. Many mutant mouse lines have been generated to provide animal models for human genetic disorders, offering insights into anatomical, neurochemical, and behavioral effects of aberrant gene expression. A variety of assays have been developed to identify and...
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