Article
Molecular landscape, subtypes, and therapeutic vulnerabilities of central nervous system solitary fibrous tumors.
Nature communications - 23 Aug 2025
Zhao Chenhui, Hu Xueyan, Guan Xiudong, Fu Xiaojun, Wang Tingting, Li Mengyuan, Liu Xinze, Zhao Jiarui, Wu Di, Zhang Fan, Fu Jiaying, Li Jiang, Zhang Tieqiang, Jiang Xiaochun, Yan Changxiang, Jia Wang, Yang Ence, Chen Jian
Abstract excerpt
Solitary fibrous tumors (SFTs) of the central nervous system (CNS) are rare, aggressive mesenchymal neoplasms with high recurrence and metastasis rates. Here, we perform a comprehensive multi-omics analysis of 189 cases of CNS SFTs integrating 94 whole genome sequencing, 88 transcriptomics, 7 single-nucleus RNA sequencing and 3 spatial transcriptome sequencing. We find that receptor tyrosine kinase mutations are...
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