Article
Solitary fibrous tumors/hemangiopericytomas with different variants of the NAB2-STAT6 gene fusion are characterized by specific histomorphology and distinct clinicopathological features.
The American journal of pathology - 1 Apr 2014
Barthelmeß Sarah, Geddert Helene, Boltze Carsten, Moskalev Evgeny A, Bieg Matthias, Sirbu Horia, Brors Benedikt, Wiemann Stefan, Hartmann Arndt, Agaimy Abbas, Haller Florian
Abstract excerpt
Recurrent somatic fusions of the two genes, NGFI-A-binding protein 2 (NAB2) and STAT6, located at chromosomal region 12q13, have been recently identified to be presumable tumor-initiating events in solitary fibrous tumors (SFT). Herein, we evaluated a cohort of 52 SFTs/hemangiopericytomas (HPCs) by whole-exome sequencing (one case) and multiplex RT-PCR (all 52 cases), and identified 12 different NAB2-STAT6 fusion...
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