Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Targeted and Shallow Whole-Genome Sequencing Identifies Therapeutic Opportunities in p53abn Endometrial Cancers.

Clinical cancer research : an official journal of the American Association for Cancer Research - 3 Jun 2024

Jamieson Amy, Sobral de Barros Juliana, Cochrane Dawn R, Douglas J Maxwell, Shankar Sameer, Lynch Branden J, Leung Samuel, Martin Spencer, Senz Janine, Lum Amy, Drew Yvette, Gilks C Blake, Huntsman David G, McAlpine Jessica N

Abstract excerpt

PURPOSE: Shallow whole-genome sequencing (sWGS) can detect copy-number (CN) aberrations. In high-grade serous ovarian cancer (HGSOC) sWGS identified CN signatures such as homologous recombination deficiency (HRD) to direct therapy. We applied sWGS with targeted sequencing to p53abn endometrial cancers to identify additional prognostic stratification and therapeutic opportunities. EXPERIMENTAL DESIGN: sWGS and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to BRCA1 Protein
Share to BRCA2 Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Class I Phosphatidylinositol 3-Kinases

Share to Cyclin E

Share to Cystadenocarcinoma, Serous

Share to Endometrial Neoplasms

Share to F-Box-WD Repeat-Containing Protein 7

Share to Oncogene Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 38536067
DOI: 10.1158/1078-0432.CCR-23-3689
PMCID: PMC11145180

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Targeted and Shallow Whole-Genome Sequencing Identifies Therapeutic Opportunities in p53abn Endometrial Cancers.PMID 38536067Read ↗

Whole-genome sequencing-based characterization of endometrial serous carcinoma.Semantic proximity Read ↗

Molecular analysis of endometrial serous carcinoma reveals distinct clinicopathologic and genomic subgroups.Semantic proximity Read ↗

Next-Generation Sequencing.Semantic proximity Read ↗

Identification of molecular subtypes for endometrial carcinoma using a 46-gene next-generation sequencing panel: a retrospective study on a consecutive cohort.Semantic proximity Read ↗

Whole genome sequencing of endometrial cancer identifies novel subgroups, drivers, and actionable alterationsSemantic proximity Read ↗

Molecular classification of endometrial carcinoma: clinical utility of an NGS panel with targeted detection of 116 cancer-related genes.Semantic proximity Read ↗

Genomic landscape of advanced endometrial cancer analyzed by targeted next-generation sequencing and the cancer genome atlas (TCGA) dataset.Semantic proximity Read ↗

Genomic and Transcriptomic Characterization Revealed the High Sensitivity of Targeted Therapy and Immunotherapy in a Subset of Endometrial Stromal SarcomaSemantic proximity Read ↗

Integrated genomic characterization of endometrial carcinomaSemantic proximity Read ↗

Identification of molecular pathway aberrations in uterine serous carcinoma by genome-wide analyses.Semantic proximity Read ↗

Genomic Analyses of Germline and Somatic Variation in High-Grade Serous Ovarian CancerSemantic proximity Read ↗

Prospective Clinical Prognostication of Endometrial Carcinomas Based on Next-Generation Sequencing and Immunohistochemistry-Real-World Implementation and Results at a Tertiary Care Center.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.