Article
Preclinical evaluation of 18F-LMI1195 for in vivo imaging of pheochromocytoma in the MENX tumor model.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine - 1 Dec 2013
Gaertner Florian C, Wiedemann Tobias, Yousefi Behrooz H, Lee Misu, Repokis Ines, Higuchi Takahiro, Nekolla Stephan G, Yu Ming, Robinson Simon, Schwaiger Markus, Pellegata Natalia S
Abstract excerpt
UNLABELLED: We evaluated (18)F-LMI1195 (1-(3-bromo-4-(3-(18)F-fluoro-propoxy)benzyl)guanidine), a metaiodobenzylguanidine (MIBG) analog, for the detection of pheochromocytoma in a preclinical in vivo model of endogenous neuroendocrine tumors (multiple endocrine neoplasia [MENX]). METHODS: Adrenal uptake kinetics of (18)F-LMI1195 were evaluated in healthy Wistar rats (n = 6) by dynamic PET imaging. Distribution of...
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