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Article

Precise modulation of BRG1 levels reveals features of mSWI/SNF dosage sensitivity

22 Aug 2025

Abstract excerpt

Mammalian switch/sucrose nonfermentable (mSWI/SNF) complex regulates chromatin accessibility and frequently shows alterations due to mutation in cancer and neurological diseases. Inadequate expression of mSWI/SNF in heterozygous mice can lead to developmental defects, indicating dosage-sensitive effects of mSWI/SNF. However, how its dosage affects function has remained unclear. Using a targeted protein...

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PMID: 40846763
DOI: 10.1038/s41588-025-02305-z

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