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Genome-wide Cox regression analysis identifies 134 novel risk loci for disability development: the Canadian Longitudinal Study on Aging and UK Biobank.

The journals of gerontology. Series A, Biological sciences and medical sciences - 19 Sept 2025

Zheng Huiping, Sun Tao, Wang Xiaojun

Abstract excerpt

BACKGROUND: Disability significantly affects the well-being of older adults and imposes substantial personal and social burdens. Although genetic effects play a role in disability, large-scale genome-wide association studies (GWAS) of disability development remain scarce. METHODS: We performed the first Cox proportional hazards GWAS on disability development on 8421 individuals aged more than 65 years from the...

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PMID: 40845153
DOI: 10.1093/gerona/glaf185

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