Combining cross-sectional and longitudinal genomic approaches to identify determinants of cognitive and physical decline.

Abstract excerpt

Large-scale genomic studies focusing on the genetic contribution to human aging have mostly relied on cross-sectional data. With the release of longitudinally curated aging phenotypes by the UK Biobank (UKBB), it is now possible to study aging over time at genome-wide scale. In this work, we evaluated the suitability of competing models of change in realistic simulation settings, performed genome-wide association...

Topics

• Humans
• Cross-Sectional Studies
• Genome-Wide Association Study
• Longitudinal Studies
• Male
• Female