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Article

Ryanodine receptor type 2 deficiency changes excitation-contraction coupling and membrane potential in urinary bladder smooth muscle.

The Journal of physiology - 15 Jul 2007

Hotta Shingo, Morimura Kozo, Ohya Susumu, Muraki Katsuhiko, Takeshima Hiroshi, Imaizumi Yuji

Abstract excerpt

The possibility that the ryanodine receptor type 2 (RyR2) can function as the major Ca(2+)-induced Ca(2+) release (CICR) channel in excitation-contraction (E-C) coupling was examined in smooth muscle cells (SMCs) isolated from urinary bladder (UB) of RyR2 heterozygous KO mice (RyR2+/-). RyR2 mRNA expression in UB from RyR2+/- was much lower than that in wild-type (RyR2+/+. In single UBSMCs from RyR2+/+, membrane...

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Source

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Identifiers

PMID: 17363382
DOI: 10.1113/jphysiol.2007.130302
PMCID: PMC2075324

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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