Article
Directly Measuring Atherogenic Lipoprotein Kinetics in Zebrafish With the Photoconvertible LipoTimer Reporter.
Arteriosclerosis, thrombosis, and vascular biology - 1 Oct 2025
Moll Tabea O C, Kiefer Julia G, Klemek Mackenzie L, Wilson Meredith H, Farber Steven A
Abstract excerpt
BACKGROUND: Lipoprotein kinetics are a crucial factor in understanding lipoprotein metabolism because a prolonged time in circulation can contribute to the atherogenic character of B-lps (ApoB-containing lipoproteins). METHODS: We developed a genetically encoded B-Lp reporter, LipoTimer, in which the zebrafish endogenous apoBb.1 (apolipoprotein Bb.1) gene was modified to produce a fusion with the photoconvertible...
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